Publications

Mark Hübener

Weiler S, Guggiana Nilo D, Bonhoeffer T et al. (2022). Functional and structural features of L2/3 pyramidal cells continuously covary with pial depth in mouse visual cortex. Cerebral Cortex, 2022; bhac303. doi

Goltstein PM, Reinert S, Bonhoeffer T, Hübener M (2021). Mouse visual cortex areas represent perceptual and semantic features of learned visual categories. Nat Neurosci. 

Bauer J, Weiler S, Fernholz M et al. (2021). Limited functional convergence of eye-specific inputs in the retinogeniculate pathway of the mouse. Neuron 109(15): 2457-2468.e12.

Reinert S, Hübener M, Bonhoeffer T, Goltstein PM (2021). Mouse prefrontal cortex represents learned rules for categorization. Nature 593:11–417.

La Chioma A, Hübener M (2021): Visual Cortex: Binocular Matchmaking. Current Biol 31 (4): R197-R199. 

La Chioma A, Bonhoeffer T, Hübener M (2020). Disparity Sensitivity and Binocular Integration in Mouse Visual Cortex Areas. J Neurosci 40 (46) 8883-8899. 

La Chioma A, Bonhoeffer T, Hübener M (2019). Area-Specific Mapping of Binocular Disparity across Mouse Visual Cortex. Current Biology 29(17): 2654-2960. 

Glas A, Hübener M, Bonhoeffer T, Goltstein PM (2019). Benchmarking miniaturized microscopy against two-photon calcium imaging using single-cell orientation tuning in mouse visual cortex. PloS One 14(4):e0214954. 

Goltstein PM, Reinert S, Glas A, Bonhoeffer T, Hübener M (2018). Food and water restriction lead to differential learning behaviors in a head-fixed two-choice visual discrimination task for mice. PLoS One 13(9): e0204066.

Kaschube M, Nelson CA, Benasich AA, Buzsáki G, Gressens P, Hensch TK, Hübener M, Kobor MS, Singer W and Sur M (2018). Early Childhood. In A. A.Benasich and U.Ribary (eds): Emergent Brain Dynamics: Prebirth to Adolescence, pp 102-123. Cambridge, MA: The MIT Press. Series: Strüngmann Forum Reports, Vol.25

Weiler, S, Bauer J, Hübener M, Bonhoeffer T, Rose T, Scheuss V (2018). High-yield in vitro recordings from neurons functionally characterized in vivo. Nature Protocols 13:1275-1293. 

Jäpel J, Hübener M, Bonhoeffer T, Rose T (2017). Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice. Nat Neurosci 20: 1708-7014. 

Rose T, Hübener M (2017). Synapses get together for vision. News & Views. Nature 547:408-410.

Clopath C, Bonhoeffer T, Hübener M, Rose T (2017). Variance and invariance of neuronal long-term representations. Phil. Trans. R. Soc. B 372:20160161. 

Keck T, Hübener M, Bonhoeffer T (2017). Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance. Curr Opin Neurobiol 43:87-93. 

Keck T, Toyoizumi T, Chen L, Doiron B, Feldman D, Fox K, Gerstner W, Haydon P, Hübener M, Lee H, Lisman J, Rose T, Sengpiel F, Stellwagen D, Stryker M, Turrigiano G, van Rossum M (2017). Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Phil. Trans. R. Soc. 372: 20160158. 

Falkner S*, Grade S*, Dimou L, Conzelmann K-K, Bonhoeffer T, Götz M*, Hübener M* (2016). Transplanted embryonic neurons integrate into adult neocortical circuits. Nature 539:248-253. 
* equal contribution

Rose T, Jaepel J, Hübener M, Bonhoeffer T (2016). Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex. Science 352:1319-1322. 

Bonhoeffer T, Hübener M (2016). Intrinsic Optical Imaging of Functional Map Development in Mammalian Visual Cortex. Cold Spring Harb Protoc. 2016(6). 

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016). Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice. Current Biol 26:956-964. 

Goltstein P, Hübener M (2015). A division of light and dark in the visual cortex. Preview. Neuron 88:624-626. 

Hübener M, Bonhoeffer T (2014). Neuronal plasticity: beyond the critical period. Cell 159: 727-737. 

Santos AF, Hübener M (2014). Chronic calcium imaging of neurons in the mouse visual cortex using a troponin C-based indicator. Cold Spring Harb Protoc. 2014(5). 

Leinweber M, Zmarz P, Buchmann P, Argast P, Hübener M, Bonhoeffer T, Keller GB (2014). Two-photon calcium imaging in mice navigating a virtual reality environment. J Vis Exp. (84). 

Djurisic M, Vidal GS, Mann M, Aharon A, Kim T, Ferrao Santos A, Zuo Y, Hübener M, Shatz CJ (2013). PirB regulates a structural substrate for cortical plasticity. PNAS 110: 20771-20776. 

Keck T*, Keller GB*, Jacobsen RI*, Eysel UT, Bonhoeffer T, Hübener M (2013). Synaptic scaling and homeostatic plasticity in the mouse visual cortex in vivo. Neuron 80: 327-334. 
* equal contribution

Liebscher S, Page R, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Guriqbal SB, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M (2013). Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Mol Psychiatry. 

McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M (2013). Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathol. 126(2):179-88. 

Tomita T, Sperling M, Cambridge SB, Bonhoeffer T, Hübener M (2012). A molecular correlate of ocular dominance columns in the developing mammalian visual cortex. Cereb. Cortex. 

Levelt CN, Hübener M (2012). Critical-period plasticity in the visual cortex. Annu Rev Neurosci 21: 309-330.

Keller GB, Bonhoeffer T, Hübener M (2012). Sensorimotor mismatch signals in primary visual cortex of the behaving mouse. Neuron, 74: 809-815. 

Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F (2011). Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nat Med. 18(1):166-71. 

Kreile AK, Bonhoeffer T, Hübener M (2011). Altered visual experience induces instructive changes of orientation preference in mouse visual cortex. J Neurosci 31: 13911-13920.

Keck T, Scheuss V, Jacobsen RI, Wierenga CJ, Eysel UT, Bonhoeffer T, Hübener M (2011). Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex. Neuron 71: 869-882.

Hübener M, Bonhoeffer T (2010). Searching for Engrams. Neuron 67: 363-371. 

Holtmaat A, Bonhoeffer T, Chow D, Chuckowree J, De Paola V, Hofer SB, Hübener M, Keck T, Knott G, Lee W-CA, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L (2009). Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nature Protocols 4: 1128-1144. 

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2009). Experience leaves a lasting structural trace in cortical circuits. Nature 457: 313-317. 

Mank M, Ferrão Santos A, Direnberger S, Mrsic-Flogel TD, Hofer SB, Stein V, Hendel T, Reiff DF, Levelt C, Borst A, Bonhoeffer T, Hübener M, Griesbeck O (2008). A genetically encoded calcium indicator for chronic in vivo two photon imaging. Nature Methods 5: 805-811. 

Keck T, Mrsic-Flogel TD, Vaz Afonso M, Eysel UT, Bonhoeffer T, Hübener M (2008). Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex. Nat Neurosci 11: 1162-1167. 

Hübener M, Hofer SB, Mrsic-Flogel TD (2008). Ocular dominance plasticity. In L.M. Chalupa and R.W. Williams (eds): Eye, Retina, and Visual System of the Mouse, pp 439-448. Cambridge, MA: MIT Press

Mrsic-Flogel TD, Hofer SB, Ohki K, Reid RC, Bonhoeffer T and Hübener M (2007). Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. Neuron 54: 961-972.

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2006). Lifelong learning: ocular dominance plasticity in mouse visual cortex. Curr Opin Neurobiol 16: 451-459. 

Ohki K, Chung S, Kara P, Hübener M, Bonhoeffer T, Reid RC (2006). Highly ordered arrangement of single neurons in orientation pinwheels. Nature 442: 925-929. 

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2006). Prior experience enhances plasticity in adult visual cortex. Nat Neurosci 9: 127-132. 

Mrsic-Flogel TD, Hofer SB, Creutzfeldt C, Cloez-Tayarani I, Changeux JP, Bonhoeffer T, Hübener M (2005). Altered map of visual space in the superior colliculus of mice lacking early retinal waves. J Neurosci 25: 6921-6928.

Hübener M, Bonhoeffer T (2005). Visual cortex: two-photon excitement. Curr Biol. 15(6):R205-8.

Hübener M (2003). Mouse visual cortex. Curr Opin Neurobiol 13: 413-420. 

Mrsic-Flogel T, Hübener M, Bonhoeffer T (2003). Brain mapping: new wave optical imaging. Curr Biol. 13(19):R778-80. 

Schuett S, Bonhoeffer T, Hübener M (2002). Mapping retinotopic structure in mouse visual cortex with optical imaging. J Neurosci 22: 6549-6559. 

Schuett S, Bonhoeffer T, Hübener M (2001). Pairing-induced changes of orientation maps in cat visual cortex. Neuron 32: 325-337. 

Swindale NV, Shoham D, Grinvald A, Bonhoeffer T, Hübener M (2000). Visual cortex maps are optimized for uniform coverage. Nat Neurosci 3: 822-826. 

Müller M, Stetter M, Hübener M, Sengpiel F, Bonhoeffer T, Gödecke I, Chapman B, Löwel S, Obermayer K (2000). An analysis of orientation and ocular dominance patterns in the visual cortex of cats and ferrets. Neural Comput 12: 2574-2595. 

Stetter M, Schießl I, Otto T, Sengpiel F, Hübener M, Bonhoeffer T, Obermayer K (2000). Principal component analysis and blind separation of sources for optical imaging of intrinsic signals. Neuroimage 11: 482-490. 

Hübener M, Bonhoeffer T (1999). Eyes wide shut. Nat. Neurosci. 2: 1043-1045.

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